Dr. Tzong-Yueh Chen
Dr. Tzong-Yueh Chen
Position：Chair Professor
Group：Agriculture & Aquaculture technology group
Research Interests：Fish molecular immunology, Fish breeding intelligent technology
E-mail：ibcty@mail.ncku.edu.tw
Room: 89803
Room Tel：+886-6-2757575#58216
Laboratory Tel：+886-6-2757575#58224#814
Education
| School | Department | Country | Degree | Period |
|---|---|---|---|---|
|
National Yang-Ming University |
Institute of Genome Sciences |
Taiwan |
Ph.D. |
1992.08 - 1999.05 |
|
National Yang-Ming University |
Institute of Genome Sciences |
Taiwan |
M.S. |
1988.09 - 1990.06 |
|
National Taiwan University |
Department of Horticulture |
Taiwan |
B.S. |
1984.10 - 1988.06 |
|
Institution |
Position |
Period |
|---|---|---|
| Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University |
Chair Professor |
2026.01 - present |
|
Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University |
Distinguished Professor |
2015.08 - 2026.12 |
|
University Center for Bioscience and Biotechnology, National Cheng Kung University |
Director |
2022.08 - 2024.12 |
| Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University | Chairman | 2015.08 - 2022.08 |
| University Center for Bioscience and Biotechnology, National Cheng Kung University |
Deputy Director |
2011.08 - 2022.07 |
| Agriculture Biotechnology Research Center, National Cheng Kung University | Research Fellow and Director | 2011.02 - present |
|
Institute of Biotechnology, National Cheng Kung University |
Chair |
2011.02 - 2017.07 |
| 2020 Professional and Technical Examinations | Committee of the Board of Examiners | 2020.10 - 2021.01 |
|
Agricultural Affairs Advisory Committee , Tainan City Government |
Member |
2020.07 - 2022.07 |
| Fisheries Advisory Committee , Fisheries Agency, Council of Agriculture | Member | 2020.03 - 2022.02 |
|
Taiwan Aquaculture Development Foundation |
Managing Director |
2021.06 - present |
| Fisheries Agency, Council of Agriculture | Member of the Review Panel for Genetically Modified Aquatic Animals and Plants Committee | 2016.02 - 2022.02 |
|
Taiwan Aquaculture Development Foundation |
Standing Director |
2018.06 - 2021.06 |
| The Fisheries Society of Taiwan | Director | 2019.02 - present |
|
Taiwan Marine Biotechnology Society |
Standing Director |
2018.12 - present |
| Fish Breeding Association Taiwan | Standing Director | 2012.03 - present |
|
|
Patent Attorney of Taiwan (No07472) |
2003.07 - present |
| Public Health Bureau of Tainan City Government | Member of the fines review panel for major violations of the Food Safety and Hygiene Management Law | 2012.12 - 2018.12 |
|
Taiwan Marine Biotechnology Society |
Standing Director |
2022.08-now |
| Taiwan Aquaculture Development Foundation | Director | 2015.06 - 2018.06 |
|
Institute of Biotechnology & Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University |
Distinguished Professor and Chair |
2015.08 - 2017.07 |
| 2016 Civil Service Junior and Senior Examination | Committee of the Board of Examiners | 2016.08 - 2016.11 |
|
2015 Special Examination for Local Government |
Committee of the Board of Examiners |
2015.11 - 2016.02 |
| Institute of Biotechnology | Professor and Chair | 2012.08 - 2015.07 |
|
Agriculture Biotechnology Research Center |
Associate Research Fellow and Director |
2011.02 - 2012.07 |
| Institute of Biotechnology | Associate Professor and Chair | 2010.02 - 2012.07 |
|
Fish Breeding Association Taiwan |
Director |
2003.05 - 2012.03 |
| Agriculture Biotechnology Research Center | Associate Research Fellow | 2007.08 - 2011.01 |
|
Institute of Biotechnology |
Associate Professor |
2007.08 - 2010.01 |
| Intellectual Property Office | Adjunct Patent Examiner | 1993.03 - 2008.12 |
|
Institute of Biotechnology |
Assistant Professor |
2001.08 - 2007.07 |
| Agriculture Biotechnology Research Center | Assistant Research Fellow | 2001.08 - 2007.07 |
|
Division of Molecular and Genomic Medical Research |
Postdoctor Research Fellow |
1999.08 - 2001.07 |
| Institute of Molecular Biology , Academia Sinica | Postdoctor Research Fellow | 1999.05 - 1999.07 |
|
Institute of Molecular Biology , Academia Sinica |
Research Assistant |
1992.06 - 1992.08 |
|
Name of Award |
Year of Award |
|---|---|
|
2022 K.T. Li Honorary Scholar Award, National Cheng Kung University, Taiwan |
2022 |
|
2021Future Tech (FUTEX) , Ministry of Science and Technology, Taiwan |
2021 |
|
2020 Outstanding Industry-University Cooperation Award, National Cheng Kung University, Taiwan |
2020 |
|
2019 Outstanding Research Award, Ministry of Science and Technology, Taiwan |
2020 |
|
2019 Future Tech (FUTEX), Ministry of Science and Technology, Taiwan |
2019 |
|
2015 Excellence in Bioscience Research, Biological Society of China, Taiwan |
2015 |
|
2014 Outstanding Award for Bioscience Research, The Biological Society of China, Taiwan |
2014 |
|
2014 Outstanding Award for Excellent Contributions in Industry-University Collaboration, Cheng Kung University, Taiwan |
2014 |
|
2014 21st TECO Award, TECO Technology Foundation, Taiwan |
2014 |
|
2014 Annual Grant to Reward the Special Talents of Colleges and Universities - Research Award, Ministry of Science and Technology, Taiwan |
2014 |
|
2013 Outstanding Research Award, Ministry of Science and Technology, Taiwan |
2014 |
|
2013 National Invention and Creation Award-Silver Medal Award, Intellectual Property Office, Ministry of Economic Affairs, Taiwan |
2013 |
|
2012 Award for Excellent Contributions in Technology Transfer, Ministry of Science and Technology, Taiwan |
2012 |
|
2012 Lecture of K.T. Li Sciences and Art - Golden Award of Cheng Kung University, Taiwan |
2012 |
|
2012 Taipei Biotech Awards: Industry-University Collaboration Award – Silver Medal Award, Taipei City Government, Taiwan |
2012 |
|
2012 Annual Grant to Reward the Special Talents of Colleges and Universities - Research Award, Ministry of Science and Technology, Taiwan |
2012 |
|
2012 Excellent Bio Industry Award: Annual Innovation Award, Taiwan Bio Industry Organization, Taiwan |
2012 |
|
The 9th National Innovation Award, Institute for Biotechnology and Medicine Industry, National Cheng Kung University, Taiwan |
2012 |
|
The 8th National Innovation Award, Institute for Biotechnology and Medicine Industry, National Cheng Kung University, Taiwan |
2011 |
|
Research Award of Cheng Kung University for the Plan of University Advancement |
2009 |
|
Golden Award of 2009 Crazy Idea-Innovation and Application in Biotechnology, MOEA, Taiwan |
2009 |
|
Best Poster Award of Aquaculture Europe 2008 |
2008 |
|
Research Award of Cheng Kung University for the Plan of University Advancement |
2007 |
|
Research Award of Cheng Kung University for the Plan of University Advancement |
2006 |
|
Poster Presentation Award of the 14th Joint Annual Conference of Biomedical Sciences |
1999 |
|
Poster Presentation Award of Sixth Symposium on Recent Advances in Cellular and Molecular Biology |
1998 |
Research Interests
My research mainly focuses on the viruses that cause severe deaths of marine fish species worldwide. The research from complete virus structure analysis and fish epidemiological investigations to host immune mechanisms are studied and brought fundamental solutions which can be applied in the aquaculture industry to overcome bottlenecks. This includes the analysis of the virus infection route and the mechanism of fish anti-virus immune system, the analysis of the whole structure of nervous necrosis virus with a high mortality rate and the microfluidic detection and diagnosis platform for fish pathogens developed in cooperation with the College of Engineering, and further use the principle of immune-induced antibodies, turn to inhibit the negative growth regulation protein in fish, and invent "immune-inhibition technology", which can promote the rapid growth of farmed animals and bring benefits to the global food supply. Furthermore, by using smart technology in fish breeding production system, we can cultivate high-quality grouper larvae, and meanwhile improve the efficiency and accuracy of breeding, bringing benefits to the global food supply.
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Anti-virus mechanism in fish In the process of virus invasion, the fish host can rely on the start of anti-virus mechanism to resist. Through studying the multiple pathways for viruses to infect fish, a series of mechanisms for hosts to defend against virus invasion are investigated, including crucial factors for anti-virus like Mx genes (Mx1, Mx2, Mx3), interferons system (IFN-I, IFN-γ, IFN-I receptor) and immune regulation system (IRFs) in fish. The results will speed up the development of the anti-viral method, and become molecular biomarkers to estimate the anti-virus vaccine efficacy. |
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Complete NNV crystal structure analysis We have cooperated with experts from National Synchrotron Radiation Research Center (NSRRC) and completed the three-dimensional structure analysis of nervous necrosis virus (NNV), as the world's first to find the complete structure of the virus research team. By utilizing information from the virus crystal structure, we are able to provide a design strategy for future vaccine development, developing a high-specificity target vaccine with a specific antigen epitope, that can effectively prevent invasion of the virus, bringing in a new revolution for aquaculture disease prevention. |
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Microfluidic detection platform for fish virus diagnosis The microfluidic detection platform is an automatic system combining molecular organism detection, immerging engineering and material technology, by integrating extraction of nucleic acid beads, gene amplification and optical diagnostic system diagnostic chip, through the micro-temperature control module and microfluidic transport module, the entire process of automated to rapid detection of agricultural pathogenic microorganisms. The minimized virus detection particles attribute to the past studies of our lab. Its characteristics are fast examination, high sensitivity and specificity, which make the platform an important tool in building a complete disease prevention strategy. |
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