Name：Chen, Tzong-Yueh

Current Position：Distinguished Professor

Science Group：Aquaculture  

Research Interests：fish genomics、fish immunology、microfluidic detection platform

E-mail：ibcty@mail.ncku.edu.tw

Tel：+886-6-2757575#58216

Hompage：Hompage

Laboratory：Laboratory

Education

學校 系所 國家 學位 起

Experiences

Research Interests：bioinformatic

Fish Molecular Immunology and Diagnosis

My research fields mainly focus on viruses that cause high mortality in marine cultivated fish species around the world. The researches include the analysis of virus crystal structure, epidemiology and fish immunology with industrial applications, hoping to conquer difficulties on aquaculture and come up with proper solutions. My studies contain Complete NNV crystal structure analysis, microfluidic detection platform of virus diagnosis, anti-virus mechanism in fish. I further and develop the immune-inhibition technique to promote the growth of cultured animals which benefits global food supply.

Anti-virus mechanism in fish

Through studying the multiple pathways for virus to infect fish, a series of mechanisms for hosts to defend virus invasion are studied, including crucial factors for anti-virus and immune regulation in fish. The results will speed the development of anti-viral method, and become molecular biomarkers to estimate the anti-virus vaccine efficacy.

Complete NNV crystal structure analysis

We have cooperated with experts from NSRRC and completed the three-dimensional structure analysis of NNV, providing new strategy for vaccine development and possible epitopes for high specificity of targeting to virus.

Microfluidic detection platform of fish virus diagnosis

The microfluidic detection platform is an automatic system combining molecular organism detection, immerging engineering and material technology. The minimized virus detection particles attribute to the past studies of our lab. Its characteristics are fast examination, high sensitivity and specificity, which make the platform an important tool in building a complete disease prevention strategy.

Development of immune-inhibition technique

I further apply the immunology principle and develop antigens with biotechnology. With negative regulation of growth factor, we can greatly increase speed of growth. The technique is applied to negatively-regulated melanin factor and the negative-growth factor of adipocyte which improve the quality of meat products. The technology has been transferred to many domestic and foreign companies and adapted to functional feed products.

ResearchGate

ResearchGate

Honors