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黃玲惠的個人資料

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姓名:黃玲惠

職稱:特聘教授

學群:生物醫學科技產業學群

再生醫學科技、生醫材料、組織工程、生化科技、幹細胞生物學

E-mail:lynn@mail.ncku.edu.tw

Tel:+886-6-2757575#58227

個人網頁:個人網頁

實驗室網頁:

 


學歷

學校 系所 國家 學位 起訖年月
南加州大學 生化及分子生物研究所 美國 博士 1987.09 ~ 1993.05
國立臺灣大學 農化所 中華民國 碩士 1983.09 ~ 1985.06
國立臺灣大學 農業化學系 中華民國 學士 1979.09 ~ 1983.06

經歷

服務機關 職稱 起訖年月
國立成功大學國際傷口修復與再生研究中心 特聘教授 2018-迄今
國立成功大學生物科技與產業科學系 教授/特聘教授 2015-迄今
國立成功大學醫學院臨床醫學研究所 副研究員 教授/特聘教授
國立成功大學再生醫學卓越研究中心 主任 2010-2014, 2016-迄今
國立成功大學生物科技研究所 教授 1999-2017
美國史丹福大學醫學院外科學系 客座教授 2003-2004
國立成功大學生物科技研究所 副教授 1998-1999
國立台灣大學醫學院醫學工程研究中心 副研究員兼副教授 1994-1998

 

研究領域:再生醫學科技、生醫材料、組織工程、生化科技、幹細胞生物學

Research Focuses

My laboratory of biomedical technology (BMT) aims at the advancement of regenerative medicine, which includes research and product development in the fields of biomaterials, tissue engineering and cell therapy. With more than 70 patents acquired over the last decade, my BMT lab combines knowledges and methods of biochemistry, cell biology, molecular biology, chemistry, material sciences and chemical engineering and dedicates to translate research results into industrial applications and solve the problems of clinical medicine. The core technologies in the BMT lab include production of noncontractible porous collagen matrix and high purity concentrated collagen solution, sterilization of biological materials, identification and quantification of collagen, creation of various wound dressings, novel biological adhesives, cell tissue gels, etc. to facilitate tissue regeneration. We have established a platform technology of porous collagen-based matrices to serve as tissue scaffolds which are biocompatible as well as biodegradable and can promote the process of tissue regeneration. We have found neovascularization in our invented matrices both in vitro and in vivo. With full-thickness wounds filled with matrices on the dorsal skin of guinea pigs, results demonstrated that our porous collagen-based matrices are more effective to facilitate wound healing with better quality than current best-sale clinical products. We now aim at the development of series of medical devices, such as artificial skin, novel wound dressing, biomimetic bone, etc. For the application of artificial tissue scaffolds in regenerative medicine, we also work on the plasticity of stem cells in extracellular microenvironment. Adipose tissue derived stem cells and placenta derived mesenchymal stem cells are studied on their proliferation, differentiation and morphogenesis in our matrices. Microarray and proteomics technologies are applied to investigate the signal transduction and interaction mechanism of the scaffold matrix with cells. We first published that hyaluronan kept human placenta derived-mesenchymal stem cells in a slow cell cycling mode similar to quiescence, the pristine state of stem cells in vivo, and prevented stem cells from senescence. By differential proteomic analysis, we found that associated with prominent biochemical metabolism and mitochondria functions. We also reviewed and proposed molecular mechanism of extrinsic factors affecting anti-aging of stem cells. Since human is the application target of various biomaterials and medical devices, a suitable animal model is crucial for the pre-clinical study and key to a successful translational research. Lanyu mini-pig is an endemic species in Taiwan and is promoted to be an international research animal due to its similarity to human being in body size, body weight, growth curve, physiological status, organs, tissues, etc. Besides Lanyu pigs can be handled and managed easily, our study demonstrated them to be a better model system with similar human wound healing profiles. In addition, the healing process as well as remodeling phase were similar between Lanyu and Landrace pigs, a well-known skin wound healing model. Our study also provides a systematic information on the biological changes of skin during the maturation process of Lanyu pig, which resemble significant changes of human skin properties from infants to elders. We have also successfully established a diabetic Lanyu pig model, skin wound healing model, bone fracture model, ischemic heart model and hind limb severe ischemia model for translational research.

 

論文著作

ResearchGate

 

榮譽奬項

項目 獲獎年
科技部傑出研究獎 2017
教育部生技創新創業獎醫藥生技組銀獎 2015
第十一屆國家新創獎 2014
國際傑出發明家發明終身成就獎。 2014
第十屆國際傑出發明家學術國光獎章 2014
第八屆國際傑出發明家學術國光獎章 2012
國立成功大學延攬及留住特殊優秀人才彈性薪資獎勵 2012~2017
101年度國科會(科技部)獎勵特殊優秀人才 2012
第十五屆俄羅斯阿基米德國際發明展金牌獎 2012
國立成功大學100年度產學合作成果特優教師 2012
100學年度「行政院國家科學委員會補助大專校院獎勵特殊優秀人才」之「研究優良獎」 2011
第五屆波蘭華沙國際發明競賽金牌獎 2011
99學年度「行政院國家科學委員會補助大專校院獎勵特殊優秀人才」之「研究優良獎」 2010
99學年度「李國鼎科技與人文講座」之金質獎章 2010
第七屆國家新創獎 2010
國立成功大學延攬及留住特殊優秀人才獎勵暨科技部獎勵特殊優秀人才 2010~2017
當選Fellow, Biomaterials Science and Engineering (FBSE) 2008.05

 

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